HYL ACETOACETATE
Methyl acetoacetate
CAS: 105-45-3
Molecular Formula: C5H8O3
HYL ACETOACETATE - Names and Identifiers
| Name | Methyl acetoacetate |
| Synonyms | MAA ACM HYL ACETOACETATE Methyl acetoacetate Methyl acetoacetaten ACETYL METHYL ACETATE methyl 3-oxobutanoate ACETOACETIC ESTER (METHYL) ACETOACETIC ACID METHYL ESTER Acetoacetic acid methyl ester 3-OXOBUTYRIC ACID METHYL ESTER 3-OXBUTANOIC ACID METHYL ESTER 3-OXOBUTANOIC ACID METHYL ESTER |
| CAS | 105-45-3 |
| EINECS | 203-299-8 |
| InChI | InChI=1/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3 |
| InChIKey | WRQNANDWMGAFTP-UHFFFAOYSA-N |
HYL ACETOACETATE - Physico-chemical Properties
| Molecular Formula | C5H8O3 |
| Molar Mass | 116.12 |
| Density | 1.076 g/mL at 25 °C (lit.) |
| Melting Point | -80 °C (lit.) |
| Boling Point | 169-170 °C/70 mmHg (lit.) |
| Flash Point | 158°F |
| Water Solubility | 460 g/L (20 ºC) |
| Solubility | Soluble in water. |
| Vapor Presure | 1 hPa (20 °C) |
| Vapor Density | 4 (vs air) |
| Appearance | Transparent liquid |
| Color | APHA: ≤20 |
| Merck | 14,6009 |
| BRN | 506727 |
| pKa | 10.67±0.46(Predicted) |
| PH | 3.8 (863g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Easily absorbing moisture |
| Explosive Limit | 1.3-14.2%(V) |
| Refractive Index | n20/D 1.419(lit.) |
| MDL | MFCD00008784 |
| Physical and Chemical Properties | Characteristics of colorless transparent liquid, with aromatic flavor. melting point -80 ℃ boiling point 171.7 ℃ relative density 1.0762 refractive index 1.4184 flash point 70 ℃ solubility miscible with ethanol and ether, slightly soluble in water. |
| Use | For the pharmaceutical industry |
HYL ACETOACETATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 1 |
| RTECS | AK5775000 |
| TSCA | Yes |
| HS Code | 29183000 |
| Toxicity | LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter) |
HYL ACETOACETATE - Upstream Downstream Industry
| Raw Materials | Methyl alcohol diketene |
| Downstream Products | Methyl 3-oxopentanoate 2,4-Dihydroxy-6-methylpyrimidine Pirimiphos-methyl Diazinon Nifedipine Nitrendipine 2-Propylvaleric acid sodium salt |
HYL ACETOACETATE - Nature
Open Data Verified Data
colorless transparent liquid with aromatic flavor. The relative density was 1. 0762. Melting Point -80 °c. Boiling point 171.7 °c. Refractive index 4184. The flash point was 70 °c. Miscible with ethanol and ether, slightly soluble in water. Slightly decomposed at boiling temperature. Dark red when mixed with fecl3.
Last Update：2024-01-02 23:10:35
HYL ACETOACETATE - Preparation Method
Open Data Verified Data
esterification of diketene with methanol using concentrated sulfuric acid as catalyst, followed by crude fractionation and distillation to obtain the finished product. Diketene is obtained by the cleavage of acetic acid. See ethyl acetoacetate.
Last Update：2022-01-01 10:33:31
HYL ACETOACETATE - Introduction
It has an aromatic flavor. It is miscible with ethanol and ether and soluble in 2 parts of water. It is dark red when mixed with ferric chloride. (Microdecomposition), slightly decomposed at boiling temperature. The median lethal dose (rat, oral) was 3.0 g/kg. Stimulant
Last Update：2022-10-16 17:11:42
HYL ACETOACETATE - Use
Open Data Verified Data
organic synthesis raw materials, cellulose resin solvent, used in medicine, Pesticide Synthesis.
Last Update：2022-01-01 10:33:30
HYL ACETOACETATE - Safety
Open Data Verified Data
- This product is less toxic, rat oral LD50 3.Og/ kg. The RAT test was exposed to concentrated vapor for 8 hours and no death was observed. There is a moderate degree of irritation and anesthesia. The equipment should be closed and the ventilation of the operating place should be strengthened. The operator shall wear protective equipment.
- This product is packaged in an aluminum barrel. Note that the lid is well sealed. Store in a cool and ventilated place. Fire Protection. According to the provisions of flammable and toxic chemicals storage and transportation.
Last Update：2022-01-01 10:33:31
HYL ACETOACETATE - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | methyl acetoacetate is an intermediate of fungicides hymmezol, dimethylsulfurol, ethylsulfurol, insecticides diazinon, pyrifos, pyrimidine oxyphosphorus, herbicide imidazoleetinic acid, rodenticide, rodenticide, rodenticide, rodenticide, rodenticide, etc. It is used as a solvent for cellulose ether and a mixed solvent for cellulose resin, and is also used in organic synthesis such as pesticides, medicines, dyes, and polymer stabilizers. Used in pharmaceutical industry organic synthesis. Solvent. |
| Production method | It is prepared by the reaction of diketene and methanol. Diketene and methanol are esterified with concentrated sulfuric acid as a catalyst, and then the finished product is obtained by crude fractionation and rectification. Diketene is obtained by cleavage of acetic acid. See "Ethyl acetoacetate". The preparation method of methyl acetoacetate is similar to the preparation method of ethyl acetoacetate. The crude product is obtained by the reaction of diketene and methanol under the catalysis of sulfuric acid, and the finished product is obtained by rectification. |
| auto-ignition temperature | 536 °F |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:05
Supplier List
Spot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Methyl Acetoacetate Visit Supplier Webpage Request for quotationCAS: 105-45-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
CAS: 105-45-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 105-45-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-531-88872378
Email: jnhuifengda@163.com
Mobile: +86-013156148719
QQ: 344046944
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 105-45-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: MAA Visit Supplier Webpage Request for quotation
CAS: 105-45-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 105-45-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
CAS: 105-45-3
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
Spot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Methyl Acetoacetate Visit Supplier Webpage Request for quotationCAS: 105-45-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
CAS: 105-45-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Wechat: +86 19849939632
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 105-45-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Multiple SpecificationsSpot supply
Product Name: Methyl acetoacetate Request for quotationCAS: 105-45-3
Tel: +86-531-88872378
Email: jnhuifengda@163.com
Mobile: +86-013156148719
QQ: 344046944
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 105-45-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: MAA Visit Supplier Webpage Request for quotation
CAS: 105-45-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 105-45-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Methyl acetoacetate Request for quotation
CAS: 105-45-3
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
CAS: 105-45-3
Tel: +86-571-88162785
Email: Lucy@verypharm.com
Mobile: +86-13606544505
QQ: 472954302
Product List: View Catalog
View History
Raw Materials for HYL ACETOACETATE
Downstream Products for HYL ACETOACETATE